Improving Estimates of Genetic Maps: A Maximum Likelihood Approach
نویسندگان
چکیده
منابع مشابه
Improving estimates of genetic maps: a maximum likelihood approach.
As a result of previous large, multipoint linkage studies there is a substantial amount of existing marker data. Due to the increased sample size, genetic maps estimated from these data could be more accurate than publicly available maps. However, current methods for map estimation are restricted to data sets containing pedigrees with a small number of individuals, or cannot make full use of ma...
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Inaccurate genetic (or linkage) maps can reduce the power to detect linkage, increase type I error, and distort haplotype and relationship inference. To improve the accuracy of existing maps, I propose a meta-analysis-based method that combines independent map estimates into a single estimate of the linkage map. The method uses the variance of each independent map estimate to combine them effic...
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We present CART HAGENE a new piece of software for genetic mapping. Compared to existing genetic mapping softwares, CART HAGENE has both strengths and weaknesses. The most important weakness is certainly its actual limitation to backcross-like pedigree. However, when CART HAGENE applies, it is able to order markers and produce maximum multipoint likelihood marker maps with a large number of mar...
متن کاملBayesian and maximum likelihood estimation of genetic maps.
There has recently been increased interest in the use of Markov Chain Monte Carlo (MCMC)-based Bayesian methods for estimating genetic maps. The advantage of these methods is that they can deal accurately with missing data and genotyping errors. Here we present an extension of the previous methods that makes the Bayesian method applicable to large data sets. We present an extensive simulation s...
متن کاملHAGENE: Constructing and Joining Maximum Likelihood Genetic Maps
Genetic mapping is an important step in the study of any organism. An accurate genetic map is extremely valuable for locating genes or more generally either qualitative or quantitative trait loci (QTL). This paper presents a new approach to two important problems in genetic mapping: automatically ordering markers to obtain a multipoint maximum likelihood map and building a multipoint maximum li...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2006
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2006.00532.x